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Case SummaryMrs. Gurbachan Kaur, a 79-year-old woman with a known history of autosomal dominant polycystic liver disease (PLD) and chronic hepatitis C infection, presented to the hepatology clinic on 05th October 2025 for a scheduled follow-up review.Her condition is serious and life-limiting, requiring careful symptom Management.She reported progressive abdominal distension, right upper-quadrant discomfort, fatigue, poor appetite, and unintentional weight loss over the preceding three months.Her past medical history includes:
  • Chronic hepatitis C virus (HCV) infection — previously treated with Peg-interferon and Ribavirin, with null virological response
  • Advanced chronic kidney disease (CKD) — serum creatinine 511 μmol/L
  • Autosomal dominant polycystic liver and kidney disease
She denied alcohol intake, smoking, or exposure to hepatotoxic substances.DiscussionMrs. Gurbachan Kaur’s case represents a serious and advanced multisystem disorder in an elderly patient. Her chronic hepatitis C infection led to cirrhosis (stage 4/4 fibrosis), which predisposed her to the development of hepatocellular carcinoma. The co-existing polycystic liver disease complicated hepatic architecture and delayed diagnosis.
  • Avoid hepatotoxic drugs and dehydration.
  • Oncology and nephrology consultations advised for integrated supportive management.
  • Regular follow-up for liver function, renal profile, and general condition.
However, Mrs. Kaur expressed her wish to return to Australia to be with her family and seek further consultation and support there.Prognosis
  • Overall prognosis: Poor
  • Stage: BCLC C (intermediate-to-advanced HCC)
  • Primary goal: Palliative management and quality-of-life maintenance
ConclusionOn 5th October 2025, Mrs. Gurbachan Kaur (born 01 December 1945) was reviewed in the hepatology clinic and diagnosed with hepatocellular carcinoma arising in a cirrhotic liver due to chronic hepatitis C, with coexisting autosomal dominant polycystic liver and kidney disease and advanced renal failure. Given the serious nature of her illness and her fragile condition, she was advised against travel; however, she has opted to return to Australia to consult with her family and continue medical follow-up and supportive care there.
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